LATISSE

What is LATISSE™ (bimatoprost ophthalmic solution) 0.03%?
LATISSE™ solution is a prescription treatment for hypotrichosis used to grow eyelashes, making them longer, thicker and darker.

What is hypotrichosis of the eyelashes?
Hypotrichosis is another name for having inadequate or not enough eyelashes.

How does LATISSE™ work?
LATISSE™ is believed to affect the growth (anagen) phase of the eyelash hair cycle in two ways: first, it increases the length of this phase; and second, it increases the number of hairs in this growth phase. The exact way it works is unknown.

How do I apply LATISSE™?
LATISSE™ is a once-a-day treatment you apply yourself each evening to the base of the upper eyelashes. See the full instructions in “How to Apply” below.

How soon will I see results?
LATISSE™ users may see results starting at 4 weeks with full results after 16 weeks. The growth is gradual overnight, over time.

Is LATISSE™ a replacement for mascara?
No, LATISSE™ does not work in place of mascara. However, mascara is a nice complement to LATISSE™ to help make your new longer eyelashes look even more attractive.

Is LATISSE™ (bimatoprost ophthalmic solution) 0.03% different from nonprescription products that indicate eyelash growth?
LATISSE™ solution is the first and only prescription treatment approved by the FDA for inadequate or not having enough eyelashes, growing them longer, fuller and darker.

What if I forget to apply one night? Or a few nights?
If you miss an application or a few, don't try to catch up. Just apply the LATISSE™ treatment the next evening and stay on schedule.

What happens if I stop using LATISSE™?
If you stop using LATISSE™, your eyelashes are expected to return to their previous appearance over several weeks to months.

Can I get a prescription for LATISSE™ from any doctor?
First, ask your doctor if LATISSE™ is right for you. Although any doctor can prescribe LATISSE™, some may be more familiar with this product than others. When making an appointment, be sure to tell the receptionist that you want to find out more about LATISSE™.

What are the possible side effects of LATISSE™?
The most common side effects after using LATISSE™ solution are an itching sensation in the eyes and/or eye redness. This was reported in approximately 4% of patients. LATISSE™ solution may cause other less common side effects which typically occur on the skin close to where LATISSE™ is applied, or in the eyes. These include skin darkening, eye irritation, dryness of the eyes, and redness of the eyelids.

What should I do if I get LATISSE™ in my eye?
LATISSE™ solution is an ophthalmic drug product. If any gets into the eye, it is not expected to cause harm. The eye should not be rinsed.

Who should NOT use LATISSE™?
Do not use LATISSE™ solution if you are allergic to one of its ingredients.

What are the ingredients in LATISSE™?
Active ingredient: bimatoprost
Inactive ingredients: benzalkonium chloride; sodium chloride; sodium phosphate, dibasic; citric acid; and purified water. Sodium hydroxide and/or hydrochloric acid may be added to adjust pH. The pH during its shelf life ranges from 6.8 — 7.8.

What is skin hyperpigmentation?
This is a common, usually harmless condition in which areas of skin become darker than the surrounding skin color. This occurs when there is an increase in the melanin, the brown pigment that produces normal skin color, in the skin. Skin hyperpigmentation is a possible side effect of LATISSE™, but may be reversible after discontinuation of the product.

What is elevated intraocular pressure (IOP)?
This is a condition where the pressure inside the eye is higher than normal. LATISSE™ may decrease IOP. So talk to your doctor if you are using IOP-lowering medications. Concurrent administration of LATISSE™ and certain IOP-lowering medications in ocular hypertensive patients should be closely monitored for changes in intraocular pressure.

What should I do if I experience eye redness?
Eye redness may occur immediately after use, but should usually last only for a short period of time. Eye redness alone is not an allergic reaction or inflammation, and doesn't mean that your eyes are being harmed. Please use the LATISSE™ applicators as instructed to help to minimize the occurrence of eye redness.

Could LATISSE™ cause the color of my eyes to change?
Eye color change – iris pigmentation – was not reported in the LATISSE™ clinical trials. Iris pigmentation has occurred in patients who applied similar medications directly into the eye to treat elevated intraocular pressure/glaucoma. Keep in mind that the amount of product applied to the base of the upper eyelashes is only 5% of the volume vs. when applied directly into the eye. Most of LATISSE™ is absorbed by the skin at the upper eyelid margin. Please consult your doctor to learn more about LATISSE™.

What should I use to apply LATISSE™?
You should always only use the FDA-approved sterile applicators to apply LATISSE™ solution directly to the base of your upper eyelashes. The applicators have been specially designed and manufactured to meet FDA standards, and ensure that the correct dose of LATISSE™ is applied. This will maximize effectiveness and safety.

Why do the directions say to only apply LATISSE™ solution to the base of the upper eyelashes?
A clinical trial of LATISSE™ was conducted on patients who applied the product to the base of their upper lashes only. Applied nightly, the transfer of LATISSE™ solution from the upper to lower eyelid may occur naturally because the eyelids are closed and the eyelashes touch each other. Over application may increase the chance of experiencing side effects. To ensure safety and maximize effectiveness, please follow the directions provided.

What should I do if I experience eye itching?
Eye itching may occur immediately after use, but should usually last only for a short period of time (one to two weeks during initial use). Eye itching alone is not an allergic reaction, and doesn’t mean that your eyes are being harmed. Consult your doctor if the itching persists or you notice other symptoms as well.

LATISSE™ solution is a prescription treatment for hypotrichosis used to grow eyelashes, making them longer, thicker and darker. Hypotrichosis is another name for having inadequate or not enough eyelashes.

Important Safety Information
Do not use LATISSE™ solution if you are allergic to one of its ingredients.

LATISSE™ solution is intended for use on the skin of the upper eyelid margins at the base of the eyelashes. DO NOT APPLY to the lower eyelid. If you have a history of abnormal IOP, you should only use LATISSE™ under the close supervision of your physician.

LATISSE™ use may cause darkening of the eyelid skin which may be reversible. Although not reported in clinical studies, LATISSE™ use may also cause increased brown pigmentation of the colored part of the eye which is likely to be permanent.

You should tell your physician you are using LATISSE™ especially if you have a history of eye pressure problems. You should also tell anyone conducting an eye pressure screening that you are using LATISSE™.

The most common side effects after using LATISSE™ solution are an itching sensation in the eyes and/or eye redness. This was reported in approximately 4% of patients.

LATISSE™ solution may cause other less common side effects which typically occur on the skin close to where LATISSE™ is applied, or in the eyes. These include skin darkening, eye irritation, dryness of the eyes, and redness of the eyelids.

Please see Full Prescribing Information below.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

• Full Prescribing Information |
LATISSE™ Q&A section is extracted from the website by ALLERGAN © 2009 Allergan, Inc. Irvine , CA 92612 . ® and ™ marks owned by Allergan, Inc.

LATISSE™
How to Apply
A FEW SIMPLE STEPS CAN LEAD TO GREAT LASHES
Like every routine, applying LATISSE™ (bimatoprost ophthalmic solution) 0.03% is all about consistency and precision. Once you follow the basic guidelines, the results will come gradually over time. To see the full effect of your eyelash transformation, take a "before" picture before you start the treatment, and keep taking pictures every 4 weeks to chart your progress.

Directions for nightly use:
Step 1 - Before Applying
Before applying LATISSE™ each night, ensure your face is clean, makeup and contact lenses are removed, and any other facial care products have already been applied.

Step 2 - Prepare the Applicator
Remove an applicator from its tray. Then, holding the sterile applicator horizontally, place one drop of LATISSE™ solution on the area of the applicator closest to the tip but not on the tip.

Step 3 - Apply to Skin using Applicator
Immediately draw the applicator carefully along the skin at the base of the upper eyelashes (where the eyelashes meet the skin) just as you would apply liquid eyeliner. This area should feel lightly moist without runoff.

Step 4 - Blot Excess
Blot any excess solution beyond the eyelid with a tissue.

Step 5 - Dispose of Applicator
Dispose of the applicator after one use. Repeat for opposite eyelid, using a new sterile applicator to help minimize any potential for contamination from one eyelid to another.